In collaboration with Hapuarachchige group (JHU, Baltimore, US) we used the trans-cyclooctene click chemistry to functionalize our 5D3 mAb targeting prostate-specific membrane antigen (PSMA) with an Aurora A kinase inhibitor MLN8237. The resulting ADC showed high potency an selectivity in controlling the growth of PSMA-positive tumors in preclinical animal models of prostate cancer with minimal side effects. Congratulation to all co-authors on this interesting story!
In collaboration with Hapuarachchige group (JHU, Baltimore, US) we used the trans-cyclooctene click chemistry to functionalize our 5D3 mAb targeting…
Time to move on… Marek is leaving our lab to meet his future life and scientific challenges as a postdoctoral…
Congratulations to Sarka on her excellent presentation at the IBT Student Days, where she was awarded first place in the…
Congratulation to Gargi on her successful PhD defense at the Immunology department, Charles University, Prague. Great job and a major…
A warm welcome to Ruzena, who joined our lab as a research assistant. Looking forward to our future collaboration!
Warm welcome to Pavlína, who joined our lab as a research assistant. Looking forward to our future collaboration!
Warm welcome to Júlia, who joined our lab as a research assistant. Looking forward to our future collaboration!
Congratulations to Zorka on her first first-author manuscript published in J Chem Inf Model, where we provide detailed characterization of…
In collaboration with Jan Dvorak group (Czech University of Life Sciences Prague) we used the C. elegans model organism to…
We secured funding from the Czech Science Foundation for our project aimed at understanding physiological functions of histone deacetylase 11…
(c) 2013, Laboratory of Structural Biology | admin
