The Laboratory of Structural Biology was established in March 2010. We investigate the molecular mechanisms of protein function using structural biology, enzymology, protein engineering, and cell-based assays. Our research focuses on selected enzyme families, including zinc-dependent hydrolases and tubulin-modifying enzymes, with the broader aim of uncovering fundamental biological principles and generating molecular tools that may support future biomedical applications.
We’re proud to share that Šárka has successfully passed her final Master’s examination. The last step toward completing her degree…
We are delighted to announce the acceptance of a new collaborative study in Scientific Reports, led by Dr. Tarawneh from…
We’re happy to welcome Kilian, who has joined our lab as a bachelor student. He will be working on his…
We are pleased to share a new study published in Cancer Letters, led by the Czech Centre for Phenogenomics (Institute…
Congratulations to Gargi Das and co-authors on their new PLOS ONE publication reporting a bispecific protein, 5D3-CP33, that activates monocytes…
We are proud to contribute to a newly published study in Cellular and Molecular Life Sciences led by Z. Cvackova…
We are delighted to share our latest publication in ACS Omega, reporting the first crystal structure of PSMA-617 and revealing…
We are pleased to announce the publication of our recent collaborative study with Hapuarachchige group (Johns Hopkins University, Baltimore) in ACS…
In close collaboration with colleagues from Masaryk University, CEITEC and Institut Curie, we have discovered a novel polyglutamylation mechanism that…
In collaboration with the Laboratory of Transgenic Models of Diseases and the Czech Centre for Phenogenomics, we have contributed to…
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