ACS Chem Biol manuscript!


Congratulations to Lucia on her first first-author manuscript published in ACS Chem Biol, where we investigated  the hydrolysis of oxadiazole-based inhibitors by human HDAC6. The detailed mechanistic view of the hydrolysis was based on inhibitor SAR (I. Snajdr, IOCB, Prague, Czech Republic) and supported by structural, biochemical, and computational data (L. Rulisek, IOCB, Prague, Czech Republic) as well as contributions from our long-term collaborators (M. Schutkowski, A. Kozikowski).