Bioorganic Chemistry manuscript!


As a result of our long-lasting collaboration with Mike Schutkowski group (Martin-Luther-Universität Halle-Wittenberg, Halle), we have developed a new continous fluorescence assay for the facile determination of histone deacetylase 11 and sirtuin enzymatic activities. The assay exploits a unique PET fluorophore quenching strategy to design highly efficient probes.