In collaboration with the Christianson lab (University of Pennsylvania, USA) and StarWise Therapeutics, LLC, we have published a manuscript that provides structural basis for the selective inhibition of HDAC6, an important target for cancer chemotherapy and the treatment of neurodegenerative diseases, by a mercaptoacetamide inhibitor.
A warm welcome to Ruzena, who joined our lab as a research assistant. Looking forward to our future collaboration!
Warm welcome to Pavlína, who joined our lab as a research assistant. Looking forward to our future collaboration!
In collaboration with Sippl and Schutkowski labs (Halle, Germany) we used the AlphaFold models of HDAC11 for structure-based virtual screening…
Warm welcome to Júlia, who joined our lab as a research assistant. Looking forward to our future collaboration!
Congratulations to Zorka on her first first-author manuscript published in J Chem Inf Model, where we provide detailed characterization of…
In collaboration with Jan Dvorak group (Czech University of Life Sciences Prague) we used the C. elegans model organism to…
We secured funding from the Czech Science Foundation for our project aimed at understanding physiological functions of histone deacetylase 11…
Congratulation to Shivam on his successful PhD defense at the Faculty of Natural Sciences, Charles University, Prague. Great job, Dr….
Congratulations to Gargi on her first first-author manuscript published in ACS Pharmacol Transl Sci! Here we describe the engineering and…
Warm welcome to Margareta, who joined our lab as a PhD student. Her work will focus on characterization of the…
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