In collaboration with Alan Kozikowski group (Starwise Therapeutics) we designed, synthesized and evaluated a series of PSMA inhibitors derived from 2-aminoadipic acid, a building block that has not previously been used to construct PSMA ligands (published in ACS Med Chem Lett). These ligands with picomolar affinity for PSMA can serve as a scaffold for the development of theranostics targeting prostate carcinoma. Congratulation to Zorka and Lucka for excellent job!
Warm welcome to Honza, who joined our group as a postdoctoral fellow! Honza will bring to our lab his expertise…
Congratulations to Jana on her successful graduation (understandably Cum Laude!) in Macromolecular and Biophysical Chemistry. Excellent work, Jana! Looking forward…
In collaboration with the Villagra lab (The George Washington University, DC, USA) and StarWise Therapeutics, LLC, we demonstrated that selective…
Warm welcome to Marketa, who joined our group recently! She will assist several ongoing projects aimed at the structural and…
Warm welcome to Lucia, who “officially” joined our group at the beginning of 2019! We can thus continue our past…
As a collaborative work of several laboratories, lead by A. Kozikowski, StarWise Therapeutics, USA, we published a manuscript detailing the…
Congratulation to Zsofia on her junior GACR grant focused on the development of new inhibitory scaffolds targeting human glutamate carboxypeptidase…
In collaboration with the Christianson lab (University of Pennsylvania, USA) and StarWise Therapeutics, LLC, we have published a manuscript that…
Our manuscript providing structural and computational basis of interactions between human glutamate carboxypeptidase II and carbamate-based inhibitors has been accepted…
Warm welcome for Daria Khuntsaria,University of Chemistry and Technology, Prague, who joined our lab recently as a diploma student! Her…
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