Resources
Pubmed – comprises more than 25 million citations for biomedical literature from MEDLINE, life science journals, and online books.
CCP4 – software for macromolecular X-ray crystallography.
RCSB Protein Data Bank – provides information about the 3D shapes of proteins, nucleic acids, and complex assemblies.
EXPASY Bioinformatics Resource Portal – provides access to scientific databases and software tools in proteomics, genomics, phylogeny, systems biology, population genetics, transcriptomics etc.
PYMOL – program for looking at molecular structures and making publication quality pictures or movies.
DisulfideByDesign – a web-based tool for disulfide engineering in proteins.
Collaboration
Slusher lab
Johns Hopkins Drug Discovery
Johns Hopkins School of Medicine
Baltimore, MD, USA
GCPII inhibitors in neuropathologies
Skerra lab
Lehrstuhl für Biologische Chemie
Technische Universität München
Freising, Germany
Development of Anticalin-based diagnostics
Pomper lab
Department of Radiology
Johns Hopkins Medical Institutions
Baltimore, MD, USA
GCPII ligands for cancer imaging
Berkman lab
Department of Chemistry
Washington State University
Pullman, WA, USA
Phosphorus-based inhibitors of GCPII
Konvalinka lab
Proteases of Human Pathogens
Institute of Organic Chem & Biochem
Prague, Czech Republic
Physiological functions of GCPII
Schutkowski lab
Post-translational Protein Modifications
Martin-Luther University Halle-Wittenberg
Halle, Germany
Substrate profiling of histone deacetylases
Running grant support:
The Ministry of Education, Youth and Sport:
LX22NPO5102 The National institute for cancer research. 2022 – 2025.
The Czech Science Foundation:
GA22-25365S Understanding cell compartment and liquid phase restricted functions of Dishevelled. 2022 – 2024.
Grant Agency of the Charles University:
GAUK-358321 PSMA-specific Antibody Fragments in Cancer Immunotherapy (Gargi Das). 2021 – 2023.
The Czech Science Foundation:
GA21-31806S Modulation of structural and functional properties of the HSP90 chaperone machinery by
reversible acetylation. 2021 – 2023.
The National Institutes of Health:
1R01CA249248-01A1 Development of selective HDAC6 inhibitors to improve cancer immunotherapy. 2021 – 2026
Past grants:
Grant Agency of the Charles University:
GAUK-1414120 Structure-function studies of tubulin-polyglutamylase TTLL11 (Jana Nedvedova). 2020 – 2022.
The Ministry of Education, Youth and Sport:
LTAUSA18196 Recombinant antibody molecules for in vivo imaging and therapy of prostate cancer (Zora Novakova). 2019 – 2022.
The Czech Science Foundation:
19-22269Y Development of non-canonical inhibitors of glutamate carboxypeptidase II: structure-activity
relationship studies and biological activity (Zsofia Kutil). 2019 – 2021.
Academy of Sciences of the Czech Republic:
PostDoc fellowship for Honza Komarek. 2019 – 2021
The Czech Science Foundation:
GA18-14167S Orthologs of glutamate carboxypeptidase 2 in basal organisms. 2018 – 2020.
Grant Agency of the Charles University:
GAUK-1678218 Analysis of interactions between histone deacetylase 6 and cytoplasmic dynein – an integrative approach. 2018 – 2020.
The Czech Science Foundation:
GA18-04790S Engineered antibodies as theranostic reagents for cancer imaging and therapy. 2018 – 2020.
Grant Agency of the Charles University:
GAUK-1558218 Popis interakcí mezi tubulinem a histondeacetylasou 6 na molekulární úrovni. 2018 – 2020.
Czech Health Research Council:
17-32727A Innovative strategies for personalized medicine: molecular approaches targeting the impact of
inherited metabolic diseases caused by PPO mutations. 2017 – 2020.
Academy of Sciences of the Czech Republic:
PostDoc fellowship for Zsofia Kutil. 2016 – 2017
The Czech Science Foundation:
GA15-19640S Molecular basis of substrate recognition by histone deacetylase 6. 2015 – 2017.
The Czech Science Foundation:
GAP301/12/1513 Novel biologics for cancer imaging. 2012 – 2016.
Ministry of Education, Youth and Sports:
CZ.1.07/2.3.00/30.0045, Biotechnological expert in structural biology and gene expression, OP Education for Competitiveness. 2012 – 2015.
The European Molecular Biology Organization:
1978, Installation Grant. 2010 – 2015.
IRG Reintegration Grant:
249220, Design and development of novel reagents, tools, and techniques targeting human glutamate carboxypeptidases II and III, Marie Curie Actions – Seventh Research Framework Programme People. 2010 – 2014.
Academy of Sciences of the Czech Republic:
Fellowship Jana Evangelisty Purkyně. 2010 – 2014.
Ministry of Education, Youth and Sports:
ME10031 Structure-based design of ligands and inhibitors targeting glutamate carboxypeptidase II and its homologs. 2010 – 2012.
The European Molecular Biology Organization:
ASTF 56 – 2012, Short TermFellowship. 2012.
