We have finally published the first manuscript on HDAC6 (more to come soon, stay tuned!:-). In collaboration with Kozikowski group, University of Illinois, Chicago, we describe design, synthesis and biological evauation of mercaptoacetamides as potent, selective and blood-brain barrier permeable HDAC6 inhibitors.
In close collaboration with colleagues from Masaryk University, CEITEC and Institut Curie, we have discovered a novel polyglutamylation mechanism that…
In collaboration with the Laboratory of Transgenic Models of Diseases and the Czech Centre for Phenogenomics, we have contributed to…
In collaboration with Mahboobi group (University of Regensburg, Germany) we modified Marbostat-100, an HDAC6 selective inhibitor, to significantly improve its…
We extended our in silico study carried out in collaboration with the Sippl and Schutkowski labs (Martin-Luther-University of Halle-Wittenberg, Germany)…
In collaboration with Goldman group (Georgetown university, DC, USA) we identified galectin-3-binding protein (LG3BP) as an interaction partner of human…
Many thanks to Gargi for her hard work and contributions to our research as well as “outside” lab activities during…
In collaboration with Hapuarachchige group (JHU, Baltimore, US) we used the trans-cyclooctene click chemistry to functionalize our 5D3 mAb targeting…
Time to move on… Marek is leaving our lab to meet his future life and scientific challenges as a postdoctoral…
Congratulations to Sarka on her excellent presentation at the IBT Student Days, where she was awarded first place in the…
Congratulation to Gargi on her successful PhD defense at the Immunology department, Charles University, Prague. Great job and a major…
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